Monomeric Class I Molecules Mediate TCR/CD3e/CD8 Interaction on the Surface of T Cells
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MHC multimers: expanding the clinical toolkit.
T cell recognition of specific antigen is initiated by the interaction between TCR molecules and peptide–MHC complexes (pMHC) expressed on the surface of antigenpresenting cells. Soluble pMHC molecules can substitute as ligands in this interaction, binding specifically to T cells expressing the appropriate TCR. Because the monomeric interaction of TCR–pMHC is of low avidity [1–6], multimerizati...
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The interaction of the T cell surface glycoprotein CD8 with major histocompatibility complex (MHC) class I molecules on target cells is required for effective T cell activation. Mutations in the alpha 3 domain of the MHC class I molecule can disrupt binding to CD8, yet leave antigen presentation unaffected. Here we show that such a mutation can interfere with positive and negative selection of ...
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Background: Natural Killer cells express killer inhibitory receptors specific for HLA-class I molecules. These receptors could induce signals that determine NK cells ability to mediate cytotoxicity. Purified soluble form of HLA class I molecules (sHLA) could bind to NK cell receptors and down-regulate the NK killer function. Objective: To evaluate the influence of sHLA and two monoclonal an...
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CD8(+) CTLs are essential for effective immune defense against intracellular microbes and neoplasia. CTLs recognize short peptide fragments presented in association with MHC class I (MHCI) molecules on the surface of infected or dysregulated cells. Ag recognition involves the binding of both TCR and CD8 coreceptor to a single ligand (peptide MHCI [pMHCI]). The TCR/pMHCI interaction confers Ag s...
متن کاملThe MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes.
Previous studies indicated that signaling through lymphocyte activation gene-3 (LAG-3), a MHC class II ligand, induced by multivalent anti-receptor antibodies led to unresponsiveness to TCR stimulation. Here, lateral distribution of the LAG-3 molecules and its topological relationship (mutual proximity) to the TCR, CD8, CD4, and MHC class I and II molecules were studied in the plasma membrane o...
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تاریخ انتشار 2001